Obsidian Entertainment's Matthew Rorie dropped by the official Neverwinter Nights 2 forums to announce plans for a v1.23 hotfix that will apparently alter the game's SecuROM protection. If we're lucky, maybe they'll just remove the game's DRM altogether:
In an upcoming hotfix to Patch 1.23, we will be changing how SecuROM copy protection is used in Neverwinter Nights 2. This should eliminate some of the crashes that a few people have been seeing in the patch.
We'll have more details on this soon!