The 12 Biggest Upcoming Sequels

GamePro is profiling a dozen of the most anticipated video game sequels coming down the pipeline in the not-too-distant future, including Diablo III, Mass Effect 2, and BioShock 2. A blurb on Blizzard's return to hell:
What we know:
Aside from how freakin' sweet Diablo III's new 3D engine is, most of what we know about the game so far comes down to two things: classes and skills. Of the seven playable classes in Diablo II, only the Barbarian will be returning in the sequel. The Necromancer has been replaced by the crowd-controlling, locust-spewing Witch Doctor, and the Sorceress has been reborn as a teleporting Wizard that hurls magic missiles.

As for skill trees, their core structure won't be changing much, but individual skills will be much more customizable this time around, thanks to new, hot-swappable skill runes. Runes will have different effects on different spells: a multistrike rune could make your Wizard's teleport spell spawn shadow copies of herself, or your Witch Doctor's flame skull spell bounce along the ground.

And, since you can move the runes around whenever you want, switching things up isn't a problem anymore. Those that crave change can even re-spec their entire skill trees on a whim.

What we don't know:
Ah, where to begin. Is the Lord of Terror himself really back? What are the game's last two playable classes? What sorts of bottom-of-the-tree skills can we expect to see? Where in Sanctuary will we be going, aside from Tristram and Caldeum? What sorts of changes can we expect to see on Battle.net?

Will there be a cow level? We can't help but ask ourselves such questions over and over again as the interminable wait slowly drives us mad. At least it's Blizzard we're waiting on: we can be darned sure any delays will be worth it.