It turns out Bethesda's earlier statements on Fallout 3 and DRM were not entirely accurate, as users have ran into some SecuROM issues. ReclaimYourGame reports:
Earlier this month, Bethesda Softworks promised us that Fallout 3 would have no invasive DRM scheme, and that they would go for the 'mildest form possible'. These are nothing but broken promises! In fact, Fallout 3 is shipping with SecuROM 7! Someone already got bitten by it, with a known SecuROM error: Conflict with Emulation Software detected. Now, we all know what that means! Non-invasive DRM? Of course not, Bethesda. We had hope, only for it to be a let-down. Also, Fallout 3 comes with SecuROM 7.36.0006. In short, Bethesda has betrayed us!Direct link to SecuROM patch here.
Other links worth a peruse:
How Bethesda treat people with SecuROM problems it's outrageous. Bethesda don't know anything about the DRM they use.
Bethesda's quick fix for people with problems.