The guys at No Mutants Allowed let us know that they've posted a FAQ for Fallout 3 that includes all the commentary from Bethesda up to this point. Here's a bit to get you started:
Fallout is one of the most beloved franchises of all time. Are you worried about meeting gamers' high expectations?
Todd Howard: I worry about meeting our own expectations. We take this stuff as seriously as anyone and are more critical of what we do than the fans. We're very careful in how we handle franchises. I think people can look at how we've treated the Elder Scrolls and know that we'll give the same care to Fallout. We pride ourselves in keeping franchises relevant and bringing something fresh to the market with each game. That being said, I'm sure there's a vocal minority that wants to kill us for even attempting to do it. But they wanted to kill Peter Jackson too, so you have to ignore that and just do something great that you'd love to play.