Ok, The twisted rune always kicks my butt! (can I say butt on this post?) Anyway, I use Yoshimo to trap, he kills the vampire easy, my PC kills the warrior guy easy, and I usually flood the chamber before I talk to Twisted Rune with Cloudkill. Beholder attackes, I have to fight him melee to kill, it weakens me when I do that (cloudkill), then other mage comes, casts time stop, and beats up everyone else. I'm so far dead, I haven't even seen the vampire that I heard about. I have my PC (elf kesai), Yoshimo, Keldorn (I don't have Corsamyr), Jan, Jaeira, Minsc. I'm at level 10, so everyone is pretty much the same as me.