So now I got in - but have now died three not-so-final deaths at Jezabels hands. I am playing a female Tremere who has THAU 2, DOM 1 and Firearms 3. Any advice, apart from getting some explosives? The b(i)tch is FAST!
You should be able to take her straight on with a knife and blood buff. It might take a couple tries to get the timing right and keep her in your sights. Other weapons won't work too well, you need blades for a vampire. The axe is too unwieldy for her room I think.
If that doesn't go too well, the shotgun is good against her as it knocks her down. You could hotkey 1: Knife and 2: Shotgun and switch back and forth. When she gets the edge on you in the knife fight, bring up the shotgun and knock her down to get a second to get your footing.
Also, with a Tremere one fighting strategy is melee and blood bolts - fight hand to hand, but every chance you get hit her with a blood bolt as well, since you don't have to switch weapons. This is a fun tactic.
Actually, if you are going in with full blood, you could probably just hit her really fast with 15 quick blood bolts.....you can fire blood bolts as quick as you can hit the button, but you won't get the blood back. It should take her down or at least get you close. This is a good trick for every boss with a Tremere, but it gets a little boring unless you mix it up with the strategy above.
I really enjoy playing a Tremere, it's kind of a Fighter/Wizard character. Get the third level Tremere spell as soon as you can, it's a long-lasting armor spell that will really help you in tough combat. Personally I find the level 4 and 5 Thaumaturgy powers fun but not really necessary. 2nd Level Purge is really good when you get mobbed, Blood Bolt is the best thing ever. It is pretty funny to use the 5th level power on people, it's worth seeing once for sure
I also wouldn't recommend increasing Domination, the 1st level is the one you really need. If I were you, and feel free to ignore this, I would put points into Melee, Dodge and Wits. This will be good. Dodge and Wits brings up your defense, which you will really notice, and Melee will pay off, believe me. Firearms are good but work best as a supplement to good Melee IMO. Also with a Tremere due to Blood Bolt and Trance you have other options for ranged combat anyway.