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Hey, I've having a bit of trouble completing this quest I killed everyone in the guild and it told me to go back and speak with Lucien, but when I tried to it told me he was fleeing. Does anyone know how to fix this.

There is no glitch, continue your quest.

I can't continue my quest I killed all the Brotherhood members and Lucien won't talk to me to finish the quest it just pops up and says "Lucien Lachance is fleeing!" at the top of the screen.

I can't seem to get him to say anything else even after I have knocked him unconcious.

I think what Warlord Hector is alluding to is that you may be in too much of a hurry. Are you sure that you have to talk to him right there, right now? I presume you have a save game after killing off the DB. Start looking for alternate paths. Not everything is chop-grab-confirm, chop-grab-confirm.
Frequently, when presented with an inexplicable obstacle, the problem is that you have missed something. Either you overlooked something, or underlooked something. That is, you've missed something in the past, or you're missing something in the future.
Apropos of nothing (SPOILER):
I'm reminded of chasing down a bunch of thieves, and I finally found one, collapsed, unconscious, and invisible. Nothing I tried worked, but I hung around there, trying different things. Eventually, I just stopped trying to kill him, he woke up, became visible, and told me where to go next. Sometimes you just have to wait.

why you have attacked him? you should only clear out the other members.

try it again, if you have a save. kill your brothers but no one should see that the attack the other brothers. first kill the one (If its day time) women in the city (to do this use rage or frenzy spell). the guards should do the work. Try to use the posioned apple for the others or just kill them one by one without seen. that should work.