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I've tried several different combinations of things, but I can't seem to get the best of her. Any help, hints, suggestions?

You mean, in the final battle? When she casts Blind all the time?

I suggest a combo of death scorpions and your teleporter stone. Loose some scorpions, then drop the stone, and teleport until Blind wears off. Return, and if she's still battling the scorpions, throw some hell spikes at her. She likes to use them at you, and they do work against Josephina, even if she has enormous resistance.

But your best bet are the scorpions and the stone, without question.