| Yes, DD is *extremely* random in its loot placement. Even important objects, when you find them, will often have variable positive effects. I've seen one amulet go anywhere from literally no benefits to 7 benefits, in all.
The random factor on a chest/body becomes fixed when you enter a room. So per comments I've read on Larian's site, should you want to keep loading and reolading for the best loot, be sure you do so while standing outside that room, and before you click on it.
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To the Righteous belong the fruits of violent victory. The rest of us will have to settle for warm friends, warm lovers, and a wink from a quietly supportive universe. | 
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