For the stairs in the De'Arnise Hold, the door can be opened but the top of the stairs are bricked over, that's why you can't go up there.
As for Mekrath's Domain, the stairs where Haer'Dalis is found, also cannot be used. That whole floor is reused from Durlag's Tower in BG1. The stairs you use to enter the room can be climbed to the top giving you a nice view of the Bridge District.
