And ignore any spawns, focus all your damage dealing on Xiao.
There are many tactics that work on her but using your disciplines in combo is a good start (have some blood ready though). There's no reason to hold back on them at this stage. Usually my disciplines determine my tactic.
One thing that also helps: get close and personal (even with a firearm), when you're close Xiao seems to have some trouble hitting you with her tentacles. (and any spawns)
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Flamethrower and Celerity and only using sharp weapons at the end to avoid tentacle spawning.
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I thought using cutting weapons seem to cause spawns more easily, but that might be an impression.