I've had a few weird ones:
The first time I went to Griffith Park, I was on the gonodola and just fell through the floor. Couldn't do a thing.
When at the Giovanni Mansion, I decided to try the violent approach and although I killed Bruno his body just jamp up onto the cieling and kept on firing at me. Shooting back proved useless as I got a '0' coming up eveytime I hit him.
On my most recent game, when in the downtown area, two guys were stuck standing behind each other on an empty sidewalk - it was very strange, especially when the guy at the back kept on sitting down like there was an invisable sofa.
Also, I can never get Heather to give me the good armour and then dismiss her so she wouldn't be killed - so I generally feed on her unti she's dead - and I lose humanity for my kindness - then when I get to Hollowbrooke - there she is well and alive - well not for long.
Finally, when I was ddowntown I went through the shortcut from near Confession to the hospital/hollowbrooke. I was playing a Tremere and just really beginning the game - then suddenly this ginger pigtailed girl jumps me in the alley with a flaming torch and knife - I'm assuming this was a hunter but I hadn't broken the Masquerade once and my humanity was full. I mean, there I was, an innocent bloodsucker, making her way through downtown LA on business when I was attacked - what's the world coming to?